S. Hirawat: search on Z-Library

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1

The 6-minute walk test as a new outcome measure in Duchenne muscular dystrophy

Craig M. McDonald, Erik K. Henricson, Jay J. Han, R. Ted Abresch, Alina Nicorici, Gary L. Elfring, Leone Atkinson, Allen Reha, Samit Hirawat, Langdon L. Miller

Journal:

Year:

2010

Language:

english

File:

PDF, 437 KB

english, 2010

2

Safety, Tolerability, and Pharmacokinetics of PTC124, a Nonaminoglycoside Nonsense Mutation Suppressor, Following Single- and Multiple-Dose Administration to Healthy Male and Female Adult Volunteers

Hirawat, Samit, Welch, Ellen M., Elfring, Gary L., Northcutt, Valerie J., Paushkin, Sergey, Hwang, Seongwoo, Leonard, Eileen M., Almstead, Neil G., Ju, William, Peltz, Stuart W., Miller, Langdon L.

Journal:

Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 337 KB

english, 2007

3

The Androgen Receptor: Structure, Mutations, and Antiandrogens

Hirawat, Samit, Budman, Daniel R., Kreis, Willi

Journal:

Cancer Investigation

Year:

2003

Language:

english

File:

PDF, 273 KB

english, 2003

4

Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis

Wilschanski, M., Miller, L. L., Shoseyov, D., Blau, H., Rivlin, J., Aviram, M., Cohen, M., Armoni, S., Yaakov, Y., Pugatch, T., Cohen-Cymberknoh, M., Miller, N. L., Reha, A., Northcutt, V. J., Hirawat

Journal:

European Respiratory Journal

Year:

2011

Language:

english

File:

PDF, 683 KB

english, 2011

5

Recombinant human erythropoietin use in hemolytic anemia due to prosthetic heart valves: A promising treatment

Samit Hirawat, Stuart M. Lichtman, Steven L. Allen

Journal:

American Journal of Hematology

Year:

2001

Language:

english

File:

PDF, 18 KB

english, 2001

6

Asymptomatic internal jugular venous thrombosis in patients with symptomatic subclavian vein thrombosis

Samit Hirawat, Eric Hoffer, Neeta Shah, Arunabh

Journal:

International Journal of Angiology

Year:

2001

Language:

english

File:

PDF, 115 KB

english, 2001

7

A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel topoisomerase I inhibitor, in patients with advanced solid tumors

Herbert I. Hurwitz, Roger B. Cohen, J. Patrick McGovren, Samit Hirawat, William P. Petros, Yutaka Natsumeda, Tomoko Yoshinari

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2007

Language:

english

File:

PDF, 308 KB

english, 2007

8

Talc induced transfusion independence in a patient with myelodysplasia

Samit Hirawat, A. Arunabh, Philip Schulman

Journal:

Leukemia Research

Year:

2001

Language:

english

File:

PDF, 48 KB

english, 2001

9

G.P.3.05 Phase 2 study of PTC124 for nonsense mutation suppression therapy of Duchenne muscular dystrophy (DMD)

C. Bönnemann, R. Finkel, B. Wong, K. Flanigan, J. Sampson, L. Sweeney, A. Reha, G. Elfring, L. Miller, S. Hirawat

Journal:

Neuromuscular Disorders

Year:

2007

Language:

english

File:

PDF, 46 KB

english, 2007

10

Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial

Eitan Kerem, Samit Hirawat, Shoshana Armoni, Yasmin Yaakov, David Shoseyov, Michael Cohen, Malka Nissim-Rafinia, Hannah Blau, Joseph Rivlin, Micha Aviram, Gary L Elfring, Valerie J Northcutt, Langdon

Journal:

Year:

2008

Language:

english

File:

PDF, 231 KB

english, 2008

11

I-99. A phase II efficacy study of brostallicin, a novel minor groove binder (MGB), in patients with platinum refractory or resistant non-small cell lung cancer (NSCLC)

Sandler, A., Natale, R., Blajman, C., Kalemkerian, G., Drinkard, L., Fein, L., Campbell, A., Polli, A., Vreeland, F., Hirawat, S.

Journal:

Year:

2003

Language:

english

File:

PDF, 74 KB

english, 2003

12

O-286 A phase II efficacy study of brostallicin, a novel minor groove binder (MGB), in patients (Pts) with platinum refractory or resistant non-small cell lung cancer (NSCLC)

Sandler, A., Natale, R., Blajman, C., Kalemkerian, G., Drinkard, L., Fein, L., Campbell, A., Polli, A., Vreeland, F., Hirawat, S.

Journal:

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

13

51 POSTER Phase 1 single-dose safety, PK, and food-effect study of PTC299, a novel VEGF expression inhibitor for treatment of solid tumors

S. Hirawat, S. Ramael, V. Northcutt, G. Elfring, N. Parquette-Lamontagne, T. Davis, M. Weetall, N. Almstead, W. Ju, L. Miller

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 102 KB

english, 2006

14

41* PTC124 activity in CF patients carrying stop mutations: results of a phase 2 study

E. Kerem, S. Hirawat, S. Armoni, Y. Yaakov, H. Blau, J. Rivlin, M. Aviram, D. Shoseyov, M. Cohen, V. Northcutt, G. Elfring, L. Miller, M. Wilschanski

Journal:

Journal of Cystic Fibrosis

Year:

2007

Language:

english

File:

PDF, 62 KB

english, 2007

15

PTC124 treatment over 3 months improves pharmacodynamic and clinical parameters in patients with nonsense-mutation-mediated CF

M. Wilschanski, S. Armoni, Y. Yaakov, H. Blau, D. Shoseyov, M. Cohen, S. Hirawat, G.L. Elfring, A. Reha, L.L. Miller, E. Kerem

Journal:

Journal of Cystic Fibrosis

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

16

PTC124 induces CFTR full-length production and activity in children with nonsense-mutation-mediated CF

I. Sermet-Gaudelus, T. Leal, K. De Boeck, G. Casimir, L. Hanssens, P. Hage, D. Roussel, A. Mogenet, S. Hirawat, G.L. Elfring, S. Constantine, L.L. Miller

Journal:

Journal of Cystic Fibrosis

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

17

Quantitative cough assessment in cystic fibrosis (CF)

E. Kerem, M. Wilschanski, G.L. Elfring, S. Hirawat, T. Pugatsch, A. Reha, S. Constantine, S.W. Peltz, L.L. Miller

Journal:

Journal of Cystic Fibrosis

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

18

Ambulatory quantitative waking and sleeping cough assessment in patients with cystic fibrosis

Eitan Kerem, Michael Wilschanski, Nilsen L. Miller, Thea Pugatsch, Tali Cohen, Hannah Blau, Joseph Rivlin, David Shoseyov, Allen Reha, Scott Constantine, Temitayo Ajayi, Samit Hirawat, Gary L. Elfring

Journal:

Journal of Cystic Fibrosis

Year:

2011

Language:

english

File:

PDF, 481 KB

english, 2011

19

Some Practical Considerations for Phase III Studies With Biomarker Evaluations

Goteti, S., Hirawat, S., Massacesi, C., Fretault, N., Bretz, F., Dharan, B.

Journal:

Journal of Clinical Oncology

Year:

2014

Language:

english

File:

PDF, 79 KB

english, 2014

20

Phase Ib Study of Buparlisib plus Trastuzumab in Patients with HER2-Positive Advanced or Metastatic Breast Cancer That Has Progressed on Trastuzumab-Based Therapy

Saura, C., Bendell, J., Jerusalem, G., Su, S., Ru, Q., De Buck, S., Mills, D., Ruquet, S., Bosch, A., Urruticoechea, A., Beck, J. T., Di Tomaso, E., Sternberg, D. W., Massacesi, C., Hirawat, S., Dirix

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 898 KB

english, 2014

21

Challenges in the clinical development of PI3K inhibitors

Massacesi, Cristian, di Tomaso, Emmanuelle, Fretault, Nathalie, Hirawat, Samit

Journal:

Annals of the New York Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 154 KB

english, 2013

22

Ataluren (PTC124) Induces Cystic Fibrosis Transmembrane Conductance Regulator Protein Expression and Activity in Children with Nonsense Mutation Cystic Fibrosis

Sermet-Gaudelus, Isabelle, Boeck, Kris De, Casimir, Georges J., Vermeulen, François, Leal, Teresinha, Mogenet, Agnès, Roussel, Delphine, Fritsch, Janine, Hanssens, Laurence, Hirawat, Samit, Miller, Ni

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2010

Language:

english

File:

PDF, 482 KB

english, 2010

23

PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model

Du, M., Liu, X., Welch, E. M., Hirawat, S., Peltz, S. W., Bedwell, D. M.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 676 KB

english, 2008

24

Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT

O'Brien, N. A., McDonald, K., Tong, L., von Euw, E., Kalous, O., Conklin, D., Hurvitz, S. A., di Tomaso, E., Schnell, C., Linnartz, R., Finn, R. S., Hirawat, S., Slamon, D. J.

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 2.76 MB

english, 2014

25

Overcoming Phosphatidylinositol 3-Kinase (PI3K) Activation in Breast Cancer: Emerging PI3K Inhibitors

Massacesi, Cristian, di Tomaso, Emmanuelle, Urban, Patrick, Germa, Caroline, Fretault, Nathalie, Bharani-Dharan, Bharani, Tavorath, Ranjana, Quadt, Cornelia, Coughlin, Christina, Hirawat, Samit

Journal:

The Journal of OncoPathology

Year:

2015

Language:

english

File:

PDF, 457 KB

english, 2015

26

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation

Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young-Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spie

Journal:

Clinical Pharmacology in Drug Development

Year:

2016

Language:

english

File:

PDF, 661 KB

english, 2016

27

Discovery and Development of Novel Therapies In Advanced Breast Cancer: Rapid Development of Ribociclib

Germa, C., Miller, M., Mukhopadhyay, P., Hewes, B., Caponigro, G., Scherer, S. J., Hirawat, S.

Journal:

Annals of Oncology

Year:

2017

Language:

english

File:

PDF, 159 KB

english, 2017

28

Enterococcus faecalis Endophthalmitis in Children – A 21 Year Study

Rishi, Ekta, Rishi, Pukhraj, Bhende, Pramod, Raman, Rajiv, Sen, Parveen, Susvar, Pradeep, Rao, Chetan, Therese, Lily, Hirawat, Rajshri

Journal:

Ocular Immunology & Inflammation

Year:

2017

Language:

english

File:

PDF, 426 KB

english, 2017

29

Circulating tumor DNA as a novel tool to shape clinical trial designs with the potential to impact outcomes: a focus on PI3K inhibitors

Sellami, D, Dharan, B, Wilke, C, Scherer, S J, Hirawat, S

Journal:

Annals of Oncology

Year:

2017

Language:

english

File:

PDF, 280 KB

english, 2017

30

PI3K inhibitors as new cancer therapeutics: implications for clinical trial design

Massacesi, Cristian, Di Tomaso, Emmanuelle, Urban, Patrick, Germa, Caroline, Quadt, Cornelia, Trandafir, Lucia, Aimone, Paola, Fretault, Nathalie, Dharan, Bharani, Tavorath, Ranjana, Hirawat, Samit

Journal:

OncoTargets and Therapy

Year:

2016

Language:

english

File:

PDF, 2.55 MB

english, 2016

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